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Depression can do damage and needs to be managed

A global study involving 9,000 people has found that persistent and recurring depression can lead to a shrinking of one key area of the brain.

This zone is known as the hippocampus (Greek for seahorse) and it does indeed look like one.

This is the area which helps us store long term memories and plays an essential role in connecting emotions to memories, personality, and consciousness. It can also help us with spatial navigation. It is one of the first areas of the brain to be affected by Alzheimer and explains why recent memories are such a big problem for those affected.

Research details

The depression research project involved 15 institutes from all over the world. Researchers compared people possessing normal hippocampus with those who were suffering from persistent depression. This was the largest comparative study of brain volumes ever carried out. The results showed that people who had no treatment for depression (or had recurring episodes over long periods) ended up with a smaller hippocampus.

Researchers used brain magnetic resonance imaging (MRI) and this clearly showed that two thirds of the depressed patients who had recurrences over long periods of time were the ones who had a smaller hippocampus.

The more episodes of depression a person had, the greater the reduction in hippocampus size. Prf. Ian Hickie, co-director of the research project

What are the implications for the treatment of depression?

There are a wide variety of these drugs available, including Selective Serotonin Reuptake Inhibitors, or SSRIs, which help to balance serotonin and can improve mood for some people, while others report that they just feel levelled out but flat.

There is a lot of nonsense said about antidepressants that constantly perpetuates the evils of them, but there is a good bit of evidence that they have a protective effect Prf. Ian Hickie.

Experts are now convinced that medication in treating depression is just one of the many alternatives available. So what are the options?

Why talk therapy is a valid alternative

Talking Therapy is a possible treatment for depression, with various types that can suit individual needs. The chance to talk about depression without being judged, or misunderstood cannot be overestimated. It is a great way to approach problems and possible ways of solving them. Most medications can never do that quite as effectively.

Additionally, there is a wide range of supplements and lifestyle changes which can help a patient to maintain balance and prevent relapses. These can range from exercise which helps the brain to re-wire itself in positive ways to dietary and mindfulness routines.

Research presents no conclusive results regarding the use of supplements but it seems that fish oil, and folic acid hold out some promise as part of a balanced diet.

The way forward

Depression is still not fully understood. We know that certain areas of the brain such as the hippocampus are involved, but experts are not sure how they all interlink and what mechanisms are at work.

Despite intensive research aimed at identifying brain structures linked to depression in recent decades, our understanding of what causes depression is still rudimentary. Prf. Jim Lagapoulos, co-author of the research project, Brain and Mind Research Institute, University of Sydney.

One thing is certain. We have learned from the research on the hippocampus that lack of treatment or recurring depression are affecting the brain. Processing emotions and memories are at risk. That sends a very clear message there may be other areas of the brain affected which may have more serious consequences. But this damage is in many cases also reversible.

This is why we can never ignore depression and always seek treatment when or if it should happen to us or our loved ones.

At Marlborough House Therapy Centre we work with many people who suffer from depression and have some excellent tried and tested therapies to address the condition and its debilitating symptoms.

If this is something that you, or someone you know, is battling with, please do get in touch.

Testimonial from Mark, a senior manager who experienced severe stress and felt his world was coming apart..

Mr. Marar has provided a service that is perfectly tailored to my needs, using a variety of techniques from neurolinguistics to hypnotherapy to coaching.

When I first saw Mr Marar I was in the depths of despair, suffering from a mental illness that caused me confusion and acute anxiety. It affected all aspects of my life family, work and leisure.

The journey with Mr Marar has been a revelation, enabling me to re-evaluate my life (in its entirety) over the course of several months. This process has cleared the confusion and  now enjoying a life with that is much more rewarding. The sessions with Mr Marar are relaxed, comforting and enjoyable. I always learn new things about myself, others and life generally. I can thank him enough Mark, Somerset.

*Please note results may vary from person to person


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To find out how we can help, please book in for a free initial chat.

For appointments in Taunton, Marlborough House Therapy Centre call 01823 272227

Bristol  Clifton Area, email us or call 07850373537 for appointments

For appointments in London, High Street Kensington, call 07850373537

Or E-mail us, please CLICK HERE for a contact form

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